Synthesis and Anticoccidial Activities of Novel N-(2-Aminophenyl)-2-quinazolinone-acetamide Hydrochloride
نویسندگان
چکیده
منابع مشابه
N-(2-Chlorophenylsulfonyl)acetamide
The asymmetric unit of the title compound, C(8)H(8)ClNO(3)S, contains two independent mol-ecules in which the C-S-N-C torsion angles are -71.7 (3) and 61.2 (3)°. The benzene rings and the SO(2)-NH-CO-C segments form dihedral angles of 80.2 (1) and 88.1 (2)° in the two independent mol-ecules. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains in the b-axis direc...
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In the mol-ecular structure of the title compound, C(9)H(11)NO(3)S, the N-H and C=O bonds are anti to each other, while the amide H atom is syn with respect to the ortho-methyl group in the benzene ring. The C-S-N-C torsion angle is -58.2 (2)°, indicating a twist in the mol-ecule. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into chains along the c axis.
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Quinolone antibacterials are one of the most important classes of pharmacological agents known as potent inhibitors of bacterial DNA gyrase and topoisomerase IV that efficiently inhibit DNA replication and transcription by generating several double-stranded DNA break. Some quinolone derivatives demonstrated inhibitory potential against eukaryote topoismarase II and substantial dose-dependent cy...
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In the title compound, C(9)H(9)N(3)O(3)S, the benzene ring and the N-carbamothio-ylacetamide unit are oriented at a dihedral angle of 54.82 (4)°. The dihedral angle between the ring and its attached nitro group is 28.54 (12)°. An intra-molecular, bifurcated N-H⋯(O,O) hydrogen bond generates two S(6) rings. In the crystal, inversion dimers linked by pairs of N-H⋯S hydrogen bonds generate R(2) (2...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2013
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2013.14162